Five questions, one molecule at a time
We design proteins that recognise one short stretch of DNA, measure how well they work, and follow what happens in cells, tissue and plates of ninety-six.
Six projects, one question each
Every project page lists the methods, the people and the measurements behind it.
Imaging organoids in three colours
A light-sheet pipeline that images whole organoids every twenty minutes without bleaching them.
Proteins with a built-in clock
Designs that the cell clears on a schedule, so an experiment can have a defined start and end.
Reading eighteen letters of DNA
A designed protein that recognises one eighteen-letter stretch of DNA, and the measurements that show how tightly it holds.
A thousand designs a week on one bench
An open, low-cost screening pipeline that lets one person characterise a thousand protein designs in a week.
A cryo-EM atlas of proteins on nucleosomes
Fourteen structures showing how designed proteins meet packaged DNA, and why the angle of approach matters.
Timing a protein’s search along DNA
Tracking single molecules as they slide and hop along DNA, and a two-number model that predicts how long the search takes.
What the data actually look like
Hover the plot to read values. Every panel is redrawn from the numbers in our papers, not a screenshot.
Bring us a question worth a microscope
Collaborate
You have a system, we have the structures. Most of our papers start with an email like yours.
Join the lab
PhD and postdoc places open twice a year. Read how we work, then tell us what you want to learn.
Invite a talk
Seminars, keynotes and school visits. I say yes to one outreach event a month.