Imaging organoids in three colours
A light-sheet pipeline that images whole organoids every twenty minutes without bleaching them.
Code
OR-21
Year
2026
Status
Ongoing
Modality
Light-sheet microscopy
Funding
Institute core funding
Team
Ana Ferreira, Jonas Weber, Ilse Maraval
Metric
1,280
Measured
organoids imaged
Why tissue
In a flat dish every cell looks alike. In a three-dimensional organoid, position matters, and we want to measure that rather than average it away.
The pipeline
Our light-sheet setup captures a whole organoid in three channels every twenty minutes for three days, at a light dose low enough that the sample keeps growing normally.
Early results
Signal varies systematically with position in the structure. We are now measuring chromatin state in each group to find out what the difference is.
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