A thousand designs a week on one bench
An open, low-cost screening pipeline that lets one person characterise a thousand protein designs in a week.
Code
HT-12
Year
2025
Status
Method
Modality
96-well plate screens
Funding
Institute core funding
Team
Jonas Weber, Priya Nair
Metric
1,152
Measured
designs per screen
The bottleneck
Designing proteins on a computer is fast. Measuring them was slow: a good student managed about forty a month.
The pipeline
We built it from a secondhand liquid handler, a plate reader and roughly 300 lines of Python. It plates, reads and ranks twelve plates in five days.
Share it
The protocol, parts list and code are free to use. Seven labs run it, and two have sent back improvements we have adopted.
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